F – Personální zabezpečení – přednášející, školitel nebo člen oborové rady

Název VŠ / součásti

Chemicko-technologická v Praze

FPBT

Název SP

Mikrobiologie

Jméno a příjmení

Peter Šebo

tituly

Ing. Csc.

Rok narození

1960

rozsah prac. vztahu na VŠ

0

do kdy

Přednášející

školitel

člen oborové rady

ano

Další současní zaměstnavatelé

typ prac. vztahu

rozsah

MBÚ AV ČR

Na dobu neurčitou

1,0

Přednášky v předmětech

Údaje o oboru vzdělání na VŠ a o praxi od absolvování vysoké školy

1984, inženýr kvasné chemie a bioinženýrství FPBT VŠCHT

1990, CSc. Moleklární biologie, MBÚ AV ČR

1985-86	studijní pobyt v MBÚ AV ČR
1986-89	interní vědecká aspirantura MBÚ AV ČR
1989-1995	Postdoktorální pobyt Francie, CNRS, Institut Pasteur
1995-	Vedoucí vědecký pracovník a vedoucí laboratoře MBÚ AV ČR

Přehled o publikační a další tvůrčí činnosti za posledních 5 let

P. Šebo – Primary peer-reviewed publications (as of March 2007)

Connell, T.G., Shey, M.S., Seldon, R., Ranggaka, M.X., van Cutsem, G., Simsova, M., Marcekova, Z., Sebo, P., Curtis, N., Diwakar, L., Meintjes, G.A., Leclerc, C., Wilkinson, R.J. and Wilkinson, K.A.* (2007). Enhanced Ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in HIV1-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector. Clin. Vacc. Immunol. 14, 847-854.

Basler, M., Knapp, O., Masin, J., Fiser, R., Maier, E., Benz, R., Sebo, P. and R. Osicka* (2007). Segments crucial for membrane translocation and pore-forming activity of Bordetella adenylate cyclase toxin. J. Biol. Chem. 282, 12419-12429.

Fiser, R., Masin, J, Basler, M., Krusek, J., Spulakova, V., Konopasek, I. and P. Sebo* (2007). A third activity of Bordetella adenylate cyclase toxin-hemolysin: Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities. J. Biol. Chem. 282, 2808-2820.

Basler, M.*, Linhartova, I., Halada, P., Novotna, J., Osicka, R., Weiser, J., Vohradsky, J. and P. Sebo (2006). The iron-regulated transcriptome and proteome of Neisseria meningitidis serogroup C. Proteomics 6, 6194-6206.

Vojtova, J. Kamanova, J. and P. Sebo*. (2006) Bordetella adenylate cyclase toxin: a swift saboteur of host defense. Curr. Op. Microbiol.9, 69-75.

Vojtova, J. Kofronova, O., Sebo, P. and O. Benada*. (2006) Bordetella Adenylate cyclase toxin induces a cascade of Morphological Changes of Sheep erythrocytes and localizes into clusters in erythrocyte membrane. Microscop. Res. Tech. 69, 119-129.

Basler, M., Masin, J., Osicka, R. and P. Sebo* (2006). Pore-forming and enzymatic activities of Bordetella adenylate cyclase toxin synergize in promoting lysis of monocytes. Infect. Immun. 74, 2207-2214.

Hejnova, J., Pages, D., Rusniok, C., Glaser, P., Sebo, P. and C. Buchrieser* (2006). Specific Regions of Genome Plasticity and Genetic Diversity of the commensal E. coli A0 34/86. Int. J. Med. Microbiol. 296, 541-546

Mackova, J., Stasikova, J., Kutinova, J., Masin, J., Hainz, P., Simsova, M., Gabriel, P., Hamsikova, E., Sebo, P. and S. Nemeckova*. (2006) Prime/Boost Immunotherapy of HPV16-Induced Tumors With E7 Protein Delivered By Bordetella Adenylate Cyclase and Modified Vaccinia Virus Ankara. Cancer. Immunol. Immun. 55, 39-46.

Linhartova*, I., Basler, M.; Ichikawa, J., Pelicic, V., Osicka, R., Lory, S., Nassif, X. and P. Sebo (2006). Meningococcal adhesion suppresses pro-apoptoticbgene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells. FEMS Microb. Lett., 263, 109-118.

Sheshko, V., Hejnova, J., Rehakova, Z., Sinkora, J., Faldyna, M., Alexa, P., Felsberg, J., Nemcova, R., Bomba, A. and P. Sebo* (2006). HlyA- knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets. FEMS Imm. Med. Microbiol. 47, 257-266.

Hervas-Stubbs, S., Majlessi, L., Simsova, M.. Morova, J., Rojas, M.-J., Nouze, C., Brodine, P., Sebo,. P. and C. Leclerc (2006). High Frequency of CD4_ T Cells Specific for the TB10.4 Protein Correlates with Protection against Mycobacterium tuberculosis Infection. Infect. Immun. 74, 3396-3407.

Anderson, S.T^., Williams, A.J., Brown, J.R., Newton, S.M., Simsova, M., Nicol, M.P., Sebo, P., Levin, M., Wilkinson, R.J. and K. A. Wilkinson (2006). Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testing. Amer. J. Resp. Crit. Care Med. 173, 1038-42.

Majlessi, L., Šimšová, M., Jarvis, Z., Brodin, P., Rojas, M.-J., Bauche, C., Nouze, C., Ladant., D., Cole, S.T., Sebo, P. and C. Leclerc. (2006). Increasing anti-mycobacterial Th1 cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis. Infect. Immun. 74, 2128–2137.

Tartz, S., Kamanova, J., Simsova, M., Sebo, P., Bolte, S., Heussler, V., Fleischer, B. and T Jacobs. (2006). Immunization with a circumsporozoite epitope fused to Bordetella adenylate cyclase in conjunction with CTLA-4 blockade confers protection against P. berghei liver stage malaria. Infect. Immun. 74, 2277–2285

Masin, J., Basler, M., Knapp, O., El-Azami-El-Idrissi, M., Maier, E., Konopasek, I., Benz, R., Leclerc, C. and P. Sebo* (2005) Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells. Biochemistry 44, 12759-12766.

Wilkinson, K.A., Simsova, M., Schölvinck, E., Sebo, P., Leclerc, C., Vordermeier, H.M., Dickson, S.J., Brown, J.R., Davidson, R.N., Pasvol, G., Levin, M. and Robert J. Wilkinson*. (2005). Efficient ex vivo stimulation of Mycobacterium tuberculosis specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase (CyaA) antigen toxoids. Infect. Immun. 73, 2991-2998

Prochazkova, K., Osicka, C., Linhartova, I., Halada, P., Sulc, M. and P. Sebo*. (2005). The Novel Neisseria meningitidis Outer Membrane Lipoprotein FrpD Binds the RTX Protein FrpC. J. Biol. Chem. 280, 3251-3258

Hejnova,J., Dobrindt, J., Nemcova, R., Rusniok, C., Bomba, A., Frangeul, L., Hacker, J., Glaser, P., Sebo, P. and C. Buchrieser*. (2005). Characterization of the flexible genome complement of the commensal Escherichia coli strain A0 34/86 (O83:K24:H31). Microbiology 151, 385-98

Schlecht, G., Loucka, J., Najar, H., Sebo P. and C. Leclerc*. (2004). Antigen targeting to CD11b allows efficient presentation of CD4⁺ and CD8⁺ T cell epitopes and in vivo Th₁ polarized T-cell priming. J. Immunol. 173, 6089-6097.

Vordermeier*, H.M., Simsova, M., Wilkinson, R.J., Hewinson, R.G., Sebo, P. and C. Leclerc. (2004). Recognition of mycobacterial antigens delivered by inactivated Bordetella pertussis adenylate cyclase (CyaA) toxoids by T cells from cattle with bovine tuberculosis. Infect. Immun. 72, 6255–6261.

Osička, R., Procházková, K., Šulc, M., Linhartová, I., Havlíček, V. and P. Šebo* (2004). A Novel 'Clip-and-Link' Activity of RTX Proteins from Gram-negative Pathogens: Covalent Protein Cross-linking by an Asp-Lys Isopeptide Bond upon Calcium-dependent Processing at an Asp-Pro Bond. J. Biol. Chem. 279, 24944-24956

Martín, C., Requero, M.-A., Masin, J., Konopasek, I., Goni, F., Sebo, P. and H. Ostolaza* (2004) Membrane Restructuring by Bordetella pertussis Adenylate Cyclase Toxin, A Member of the RTX Family. J. Bacteriol. 186, 3760-3765.

Šimšova, M., Šebo, P. and C. Leclerc* (2004). The adenylate cyclase toxin from Bordetella pertussis – a novel promising vehicle for antigen delivery to dendritic cells. Int. J. Med. Microbiol., 293, 571-576.

Mašín^, J., Konopásek, I., Svobodová, J. and and P. Šebo* (2004). Different Structural Requirements for Adenylate Cyclase Toxin Interactions with Erythrocyte and Liposome Membranes. Biochem. Bipohys. Acta – Biomembranes 1660, 144-154.

El-Azami-El-Idrissi, M., Bauche, C., Loucká, J., Osička, R., Šebo, P., Ladant, D., Leclerc*, C. (2003) Deciphering the interaction of Bordetella cyclase with CD11b/CD18: Role of acylation and identification of the integrin interaction domain of CyaA. J. Biol. Chem. 278, 38514-38521

Knapp, O. Maier, E. Polleichtner, G, Mašín, J., Šebo, P. and Benz*, R. (2003). Channel formation in model membranes by adenylate cyclase toxin (CyaA) of Bordetella pertussis. Biochemistry, 42, 8077-8084.

Forman, S., Linhartová, I., Osička, R., Nassif, X., Šebo, P. and V. Pelicic* (2003). Neisseria meningitidis RTX proteins are not required for virulence in infant rats Infect. Immun. 71, 2253-7.

Loucká, J., Schlecht, G., Vodolánová, J., Leclerc, C. and P. Šebo* (2002). Delivery of a MalE CD4⁺ T-Cell Epitope Into MHC Class II Antigen Presentation Pathway by Bordetella pertussis Adenylate Cyclase. Infect. Immun. 70, 1002-1005.

Působení v zahraničí

1989-95, cnrs A Inatitut Pasteur, Paris, Francie

Obor habilitačního nebo jmenovacího řízení nebo udělení vědecké hodnosti

řízení na VŠ

ohlasy publikací

Rok udělení (prof…)

mezinár.

tuzem.

Písemný souhlas přednáš., školitele, člena ob. rady s působ. v SP v daném rozsahu

895

???

Datum

16.07.07