Fourier Transform Ion Cyclotron Resonance Mass Spectrometry as the Most Precise and Flexible Method in Proteomics and its Application
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a Scientific Instruments Co., Brno, Czech Republic,, b Bruker Daltonik GmbH, Bremen, Germany
This paper reviews the application of FT-ICR mass spectrometers for various proteomic purposes and presents on several examples advantages over other mass spectrometry approaches. FT-ICR MS shows uncomparably high resolution. Numerous isolation and dissociation/fragmentation techniques, such as SORI and ECD, or their combination, give precise information about studied proteomic samples.