2025-110-23

Prodrugs of acyclic nucleoside phosphonates with antiviral properties

Vedoucí práce: prof. Andrea Brancale, Ph.D.

Konzultant: Ing. Petra Cuřínová, Ph.D.

Podstata a cíl práce

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Náplň činnosti studenta

Analogues of acyclic nucleosides and nucleotides exhibit significant antiviral activities. The aim of the bachelor thesis is the synthesis of prodrugs of acyclic nucleoside phosphonates, primarily derived from (S)-HPMPA. The prepared compounds will be generally studied as potential antivirals in collaboration with other scientific groups. Molecular modelling calculation could be also performed to rationalise the antiviral data observed.

Doplňující informace

Místo řešení: Ústav organické chemie (110)

Téma je možné zvolit pro následující specializace