Development of an LC-MS Method for the Determination of Selected PFASs in Polymeric Components

Per- and polyfluoroalkyl substances (PFASs) represent an important group of persistent anthropogenic contaminants that may be present in polymeric materials used in industrial applications. The aim of this bachelor thesis is to develop and validate a reliable analytical method for the determination of selected PFASs in polymeric components. Particular attention will be paid to the optimization of sample preparation and extraction procedures, as well as to the development of an LC-MS method suitable for the quantitative analysis of target compounds.

The student will perform a literature review focused on PFASs, their occurrence in polymeric materials, and current analytical approaches for their determination. Experimental work will include optimization of sample preparation and extraction procedures for the isolation of selected PFASs from polymeric components. Furthermore, LC-MS conditions for the quantitative analysis of target compounds will be developed and optimized. The analytical method will be validated using appropriate performance parameters and subsequently applied to the analysis of real samples. The obtained results will be evaluated and discussed with respect to the suitability of the developed methodology.