2026-112-10
Double-hydrophilic thermoresponsive block copolymers via RAFT polymerization.
Vedoucí práce: Dr. Christian Rossner
Konzultant: prof. Jan Merna
Podstata a cíl práce
Double-hydrophilic block co-polymers, in which one block displays responsivity toward external cues such as, e.g., pH, temperature, or light are of interest for the development of nanocarriers of drugs, nano(bio)sensors, and nanoscale machines. This project aims at synthesizing poly(N-isopropylacrylamide)-block-poly(ethylene glycol) copolymers with trithiocarbonate w-end terminals. These polymers provide temperature-responsive properties due to a lower critical solution temperature of one of the blocks, as well as affinity toward noble metal surfaces because of their trithiocarbonate end groups. This enables the formation of highly functional gold/polymer hybrid nanoparticles
Náplň činnosti studenta
Poly(N-isopropylacrylamide)-block-poly(ethylene glycol) copolymers with varying degree of polymerization will be synthesized by RAFT polymerization from a commercially available macroRAFT precursor. Their macromolecular structures as well as their temperature-depedent solution behavior will be studied by SEC, NMR, and dynamic light scattering experiments. Eventually, nanohybrids will be synthesized by grafting these polymers onto (citrate-reduced) gold nanoparticles. The work will be solved in framework of international project DFG-CSF.
Doplňující informace
Místo řešení: Ústav polymerů (112)