Metabolites of Endophytic Microorganisms as Bioactive Compounds
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a Department of Biotechnology, Faculty of Natural Sciences, University of Saint Cyril and Method, Trnava, b Drug Research Institute, VULM Co., Modra, c Institute of Biotechnology and Food Science, Faculty of Chemical and Food Technology, Slovak Technical University, Bratislava, d Food Research Institute, Bratislava
Higher plants are hosts of one or more endophytic microorganisms. The relationship that they establish with the plant varies from symbiotic to parasitic. The microorganisms (mostly fungi and bacteria) live in the intercellular space of plant tissue. Some endophytes produce various useful bioactive products, which may be potentially used in medicine, agriculture, and industry. Novel antibiotics, antimycotics, immunosuppressants, and anticancer compounds given in this review are examples of bioactive compounds produced by these microorganisms.