Multiresidue methods employing various chromatographic techniques are currently used for determination of a wide range of semivolatile organic contaminants that may occur in food or environmental biotic matrices. Conceivable strategies aimed at improvement of performance characteristics of such methods are presented in this paper. Examples demonstrating applicability of advanced instrumental approaches such as fast GC and GC or LC coupled with mass spectrometry are provided. The quality of generated data is discussed.