This short review is focused on potato tuber proteins their classification, importance, and potential application in practice. A new approach to classification of tuber proteins by molecular weight is mentioned. The main and most important component of tuber proteins is patatin proteins. These are a heterogeneous group of protease inhibitors and other proteins. Patatin proteins are a family of immunologically identical glycoproteins with monomer molecular weights of ca. 40 43 kDa. Multiple enzymatic activities were found in patatin proteins, but their lipid acyl hydrolase activity is predominant. Enzymatic and other biochemical properties of patatin proteins determine their future practical application in food industry. In general, potato tuber proteins are high-quality plant proteins with an excellent nutritional and biological value.